Department of Inherited Intestinal Cancer Syndromes –
The Polyposis Registry 

The Inherited Intestinal Cancer Syndromes are more commonly known as “polyposis” and/or “Lynch Syndrome”.

There are leaflets available to download providing information on the polyposis syndromes, which include:

Familial Adenomatous Polyposis (FAP)
Peutz Jeghers Syndrome (PJS)
Juvenile Polyposis Syndrome (JPS)
MYH Associated Polyposis (MAP)
Serrated Polyposis Syndrome (SPS)

The hospital department caring for these families is the Polyposis Registry. The Lynch Syndrome Families are cared for by the Family Cancer Clinic.

The Polyposis Registry was started in 1924 to record the details of patients with multiple colorectal polyps, most of whom had a family history of bowel cancer. Today the Registry continues to be involved in research, although the main focus is care of patients and their families.  Find out more about the history of the Registry.

The main aims of the Registry are:

  • Cancer prevention
  • Education
  • Research

Location Within Hospital

The St Mark’s Centre for Familial Intestinal Cancer is based in Central Middlesex Hospital Site, Acton Lane, Park Royal. St Mark’s is a world renowned specialist hospital for patients with gastrointestinal conditions.

St Mark’s Hospital
Central Middlesex
Acton Lane
Park Royal
NW10 7NS

Key Contacts

Email: LNWH-tr.SMCFIC@nhs.net
Telephone: +44 (0) 208 453 2656
Twitter: @PolyposisRegUK

PolyposisPatient 

PolyposisPatient is a support group for patients, families and friends whose lives have been affected by FAP. For more information, visit their website: https://polyposispatient.support/

Referral Guidelines

The Team

Professor Sue Clark
Clinical Director & Consultant Surgeon

Dr Andrew Latchford
Assistant Clinical Director & Consultant Gastroenterologist

Dr Warren Hyer
Paediatric Gastroenterologist 

Vicky Cuthill
Manager

Jeshu Chauan 
Nurse Practitioner

Jackie Hawkins
Paediatric Nurse Practitioner

Denise Coleman & Janet Paul
Administrators

History of the Polyposis Registry


The Polyposis Registry at St Mark’s Hospital represents possibly the longest running research project in the world. It began in 1924 when a Pathologist, Dr Cuthbert Dukes, and Mr J.P. Lockhart-Mummery, a surgeon, discussed some patients they thought to be both interesting and rare. These patients not only had multiple polyps in the bowel but also a family history of bowel cancer.

Dr Dukes was already involved in the science of polyps and cancer, and in his laboratory at St Mark’s he set the groundwork for much of the science that continues today. Mr Lockhart Mummery added to this his knowledge of recording family histories and together they set up a formal system for collecting information. They were helped by Dr Dukes’ laboratory assistant, the young HJR Bussey. This young man developed such a fascination for polyposis that by the 1960s he had been awarded a PhD for his work in polyposis and become world famous for his knowledge about the condition.

In those early days, St Mark’s Hospital was supported by voluntary contributions but today it is, of course, part of the National Health Service (NHS). The NHS does not, however, support research into polyposis. The money for this comes from charities such as Cancer Research UK and the St Mark’s Hospital Foundation.

Other pages:
Polyposis Information Day
Lynch Syndrome Information Evening